Code: AC091
KIT Name: Beta Globin Test
Description: The device provides reagents for the identification of 25 mutations of beta-globin gene (HBB), involved in type beta thalassemia, through the amplification of the target sequences, reverse-hybridization and color development. Beta thalassemias are an heterogeneous group of hereditary autosomal recessive blood disorders resulting in variable phenotypes. They are caused by a reduced (beta +) or absent (beta 0) synthesis of the beta-globin chains of the hemoglobin tetramer, due to alterations in beta-globin gene (HBB) on chromosome 11. The majority of mutations are single nucleotide substitutions, deletions, or insertions of oligonucleotides leading to frameshift. Rarely, beta-thalassemia results from gross gene deletion.
Extraction: AA1001, AA340
Detection: RDB on Strip
Test: 20
