Genetic Predispositions

MTHFR Real Time Duplex Mix, code AA1371/48

Code AA1371/48

KIT Name: MTHFR Real Time Duplex Mix

Description: The kit provides reagents for the genotyping of MTHFR (C677T and A1298C mutations) sequence gene through the amplification of target sequences and allelic discrimination test. Uracil-DNA glycosylase (UNG) enzyme to prevent contamination.
Reduced activity of Methylenetetrahydrofolate reductase leads to high homocysteine levels in plasma. In the sequence of the coding gene, two polymorphisms has been detected: C>T in position 677 and A>C in position 1298 substitution, with consequent MTHFR reduced activity. High levels of homocysteine in plasma represent a risk factor for thrombotic episodes related to the arterious system, but in association with Factor V Leiden and/or Prothrombin 20210 variants lead to an increased risk for venous thromboembolism.

Platforms: 
BioRad -CFX96 

Extraction: AA1001, AA1319/96

Detection: Real Time

Test: 48

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P.Iva/Cod.Fisc.: 08763060152 - Cap. Soc. € 110.000,00 i.v.

 

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