Genetic Predispositions

PAI 1 (4G/5G) Real Time (FRET), cod. AA1034

Cod. AA1034

KIT Name: PAI 1 (4G/5G) Real Time (FRET)

Description: Kit provides reagents for the genotyping of Plasminogen activator inhibitor-1 (PAI-1) sequence gene, which includes polymorphisms of type insertion/deletion of one G (4G/5G). This polymorphism is in the promoter region of gene and is involved in arterial and deep venous thrombosis through the amplification of target sequences and melting curve analysis. One of the factors involved in the evaluation of thrombotic risk is plasminogen activator inhibitor-1 (PAI-1); his main role is the dissolution of clots for inhibition of the conversion of plasminogen in plasmin which has fibrinolytic activity. In the promoter region of the gene coding for this protein, there is an insertion/deletion (polymorphism 4G/5G), which is associated with different levels of plasminogen in the plasma and therefore with thrombotic risk.

Platforms: 
Corbett Research / Qiagen - RotorGene
BioRad - CFX96

Extraction: AA1001, AA898

Detection: Real Time

test: 25

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