Genetic Disorders

PAI-1 / FV H1299R Real Time Duplex Mix, code AA1399/48

Code AA1399/48

KIT Name: PAI-1/FV H1299R Real Time Duplex Mix 

Description: The kit provides reagents for the genotyping of PAI-1 (PLASMINOGEN ACTIVATOR INHIBITOR-1) 4G/5G polymorphism and  coagulation Factor V H1299R (G1691A) mutation through the amplification of target sequences and allelic discrimination test. Uracil-DNA glycosylase (UNG) enzyme to prevent contamination.
Mutation in the Factor V gene, such as the HR2 haplotype (H1299R) which involves the replacement A>G at nucleotide 4070, cause thrombosis especially if associated with the R506Q mutation. Among the potential genetic markers of cardiovascular risk, the PAI-1 gene (Plasminogen Activation Inhibitor - type 1) has also been identified, which plays a critical role in the regulation of intravascular fibrinolysis. The 4G (instead of 5G) sequence presence in the promoter region has been associated with an increased risk of venous thromboembolism.

BioRad -CFX96
Qiagen - RotorGene Q 

Extraction: AA1001, AA1319/96

Detection: Real Time

Test: 48

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